Antworten zum Thema Xxx - Akne,Pickel und Mitesser

[elli_p]

hey,
kann es vll sein das das eine anfangsverschlechterung ist? da ja praktisch der ganze "dreck" raus muss. und mach dir keine gedanken, bei manchen wirkt iso erst nach 8 monaten oO warte einfach mal ab, und wenns echt nich anschlägt, frag deinen hautartzt.

lg

[joerniii]

ok danke :/
dann natürlich die frage wie der ganze dreck raus kommt ?
lg

[Leni86]

hey joerniii,

habe auch min. 3-4 monate iso nehmen müssen, bevor die akne zurückging... wann die besserung eintritt, ist von typ zu typ verschieden! bei dir wird es sicherlich eine anfangsverschlechterung sein, was absolut normal ist! irgendwann trocknen auch deine talgdrüsen aus und die dinger haben keine chance mehr ;-)
einfach nicht aufgeben, das ist das allerwichtigste!!!

[joerniii]

hey ja aufgeben werd ich auf keinen fall, aber denk auch das ich nicht die schlimmste form der akne hab deswegen verwunderts mich eben

[foxyfoxy]

Iso lohnt nur bei extremer, oder entstellender Akne, ein blick auf die Nebenwirkungen im Beipackzettel sagt ja schon alles.

Ich war Lange auf aknetheparie.de tätig,leider ist das forum nun dicht, ja es gab Leute die haben iso echt bereut, ihre pickel wurden gegen dünne rote schwitz- haut getauscht, bzw Haarausfall , Sehschwäche,Leberschaden.

Bearbeitet von foxyfoxy, 18 July 2010 - 14:55 Uhr.

[chribe]

Mal wieder ein unnötiger Beitrag, danke schön.

[Josiane]

Noch so ein "unnötiger" Beitrag: Auszüge aus einer Reportage zum Thema "Roaccutan" im italienischen Schweizer Fernsehen (übersetzt ins englische). Wer Interesse hat, mehr darüber zu lesen, hier ist der Link: Reportages

From the diary of Mauro Weick
“At night, I do sleep, but it’s a restless sleep – I wake up very tired – I have strong headaches, nausea and feel confused” “I feel a strong repulsion for everybody – and everything” “definitely, a terrible suffering”.

Michael Papantonio, lawyer
The interesting thing about this drug it’s that it was never intended for something like clearing up pimples. This was a drug that was intended for chemotherapy. ...

Chloé (Geneva)
Yes I said, I am sure that this is due to Roaccutan, but the lady, the psychiatrist she said : No it didn’t happen instantly, it happened six months later, she said I was a depressive. That’s how I was labeled.

Liam Grant
In February 1997 Liam started a 4-month course of treatment on Roaccutane. He had very mild acne. He was diagnosed 2 on a scale of 0 to 10 - he had a 4 month course which he had to do, which he was due to finish on June 20th. He died on June 15th. So at that point he had only got another few days of the course to finish.

Liam Grant
He became gradually more and more withdrawn, he spent a great amount
of time in his room and he started circulating less with his friends. In the month of May there was brightness and sunshine and he’d come out and he’d say that this was giving him terrible headaches and he wanted to stay inside. But still, we didn’t know, we never associated the drug with it because as far as we were concerned this Roaccutane was very simple, ordinary medication, a bit more than a cream, but that’s it.

Chloé (Geneva)
It was in April, I was on my bike and I wanted to throw myself under a car, I talked to my mother, right away she took me to a dermatologist and the dermatologist said no, no, it isn’t serious, but let’s stop it, then.
From then on, it got slowly worse. I started to not sleep, feel bad, deprime myself, isolate myself at school.

Karin K.
In the evening at six she had a crisis I was really desperate, I didn’t know what to do, she started to panic saying Mummy, I will die, I comforted her and at the same time I made an emergency call. With the help of the emergency doctor, we took her to the emergeny room of psychiatrics of the hospital of the canton of Geneva.

TEXT
Devastating side effects. The adverse reactions are reported to the authorities by the doctors and putted in the database of the World Health Organization. Since 1983 to nowaday, the database contains 2000 depression, 1000 between attempted and committed suicide, and all together over 6000 psychiatric adverse events related to Roaccutan. These figures should be multiplicated for 100, according to US health authorities. Because only about 1 % of adverse reactions would be reported. According to the figures, Roaccutan is provoking a massacre.

It’s called isotretinoin. Indication: cystic severe acne, resistant to other therapies. Since 4 years, generics are also available on the market.
Roaccutan is well known to cause heavy birth defects since its marketing, in 1982.
In US, the Congress have been discussing about it. The spin came from a congressman. His own son killed himself with 17.

Bart Stupak, congressman
My son went on Accutane in December 1999 and on May 14th, about 5 and a half months later he shot himself while on Accutane. This was completely out of characteristic of my son. He was a young man who loved life. He’d light up this room if he walked in right now. So after some time my wife just thought that maybe there could be some relation between Accutane and his suicide. I found that hard to believe: why would an acne medicine lead to disturbed thoughts or depression. We found that the FDA, the Food and Drug Administration here, in the United States, filed a warning in 1998. We had no knowledge of that. My first question was: why don’t people know about this? Secondly, why would the FDA in 1998 put a warning note, but not tell people? And what led to the warning. Why the warning?

Liam Grant
There was absolutely no explanation as to how he could have done this. Somebody like him who was so outgoing and had so many interests and so on. And that’s how
my investigation started. I decided to engage a full-time scientist for a period of 6 to 8 months, investigate this, see what comes out of it and write a report.

TEXT
The researcher found dozens of studies on the issue. Some of them put between 1 and 5 % the patients that would develop depression. The figure of reported suicides? The comparison with the other acne medications is striking.

J. Douglas Bremner, psychiatrist
We looked at a group of 13 individuals who were treated with isotretinoin, which is Accutane in the United States, and compared it to 15 individuals who were treated
with antibiotics. And we looked at brain function before and after treatment, with antibiotic or isotretinoin. And we found 16% decrease in brain function over the frontal cortex, which is the brain region involved in emotion and mood, in the patients treated with isotretinoin, but not in the patients treated with antibiotic.

Konrad Michel, psychiatrist
This is a single study with a small number of patients. The results are anyway impressing. The researchteam is an established team of Dr. Bremner and Charles Nemerov as senior authors, published in the American journal of psychatry as a famous journal. It is clear that this is a finding which matches the findings about depression and suicide .
For our clinical practice this study means that we do increasingly pay attention to the use of Roaccutan in young people, that we got used to ask regularly this people when entering, also ambulant patients, if this drug has been taken by them. We do believe that this makes sense as a precaution.

Mike Papantonio, lawyer
If you, today, were to ask Roche: Explain to me what is the mechanism, the bio mechanism of this drug. You know what? They wouldn’t be able to tell you. They don’t know. This drug has been on the market since 1982 and they have not spent one dime, not one single dime, trying to figure out how it works, how it goes about causing these side effects.

But let’s have together a closer look to this difference. In the US label, the absolute forbid to assume Roaccutan during a pregnancy, have a great evidence. But what strikes, is the detailed list of symptoms.

"Stop taking the medication and call right away the doctor if you start to feel sad or have crying spell, lose interest in activities you once enjoyed, have trouble concentrating, withdraw from your friends or family, have feelings of worthlessness or guilt, start seeing or hearing things that are not real"

Journalist
Would'nt such a list also be useful for swiss doctors?

Andres Schneider, Swissmedic
We simply assume, that the doctors have personal responsibility. They are specialists, who have the information either in their head or they know where to find it.

Karin K.
I called the dermatologist and asked for an explanation. You know all these things. My daughter has told you. But you know your daughter didn’t have any sign of depression. I said yes, because my daughter isn’t depressive. And the, he adds: there is nothing written about Roaccutan dangers in any litterature. I said: What, are you kidding me ?!

Journalist
We detected that many dermatologists have the tendency to tell their patients that there is surely no relation between the taking of Isotretinoin and depression. Are you worried about that?

Andres Schneider, Swissmedic
Yes, because it does not accord to what we write in the label. We did see it, for exemple, after we issued the information to the pharmacists about the prescribing restrictions to women. We did receive some feedback that they hadn’t known about this before. So probably there are actions needed and we will take some more measures to make the information better.

TEXT
While Swissmedic thinks about it, the Health Department of the Swiss state Ticino decided to take action. First in the country, the Swiss canton is going to send to dermatologists and psychiatrists a questionnaire, to understand better what do they know about Roaccutan. Together, a fat documentation, with the report figures and the published researches, will be sent to them all.

Patrizia Pesenti, Health minister of Ticino
The goal is to improve the information. We’re only going to collect data, about the present situation. But afterwards, scientifical studies are needed, which should assess the relationship between this drug and the psychiatric adverse events. It is very important that these studies are completely independent. They must be independent, independent from the pharma industry.

[Josiane]

TEXT
September 2006. Bath University, in England, and Texas University published together a new, independent study about Roaccutan. We went to Austin, Texas, to meet and interview the professor Michelle Lane, who did realize it.

Michelle Lane, researcher
So what we did was we took two groups of mice. Mice were adolescent, and one group of mice received an injection of the drug at the same dose that’s given to human patients. Another group of mice just received an injection. And the mice received either just an injection or just the drug for six weeks. And at the end of the 6 weeks the mice were put through a variety of behavioral tests and these are really commonly used tests - they’re actually used to study antidepressants. The attempt of these tests is to model what is happening in humans, but of course a mouse isn’t a human and you can’t ask a mouse: Are you sad? You can measure this lack of desire to escape from a bad situation and that is, in theory, related to a human being’s lack of motivation in depression. So the results of our research were that in adolescent mice the same dose of Accutane that’s given to humans causes an increase in this depression-related behavior.

TEXT
Michelle Lanes study made the One on the international media. Headline: “That’s the scientifical evidence of the link between Roaccutan and depression”.
What about the Swiss media? They simply ignored it.
But in the same days, they were actually reporting about Roche: there was the Open door day in the Basel headquarters. Open doors to everybody - but please, no inconvenient questions: to our request to comment the latest studies, the company's doors stay locked. Roche wrote us: our position didn’t change and we don't wish to participate to your program.

Heinz Weick
He was the kind of son that every parent wish to have. He was hot for his studies, was outgoing and funny. He was thinking about becoming a journalist – or something like that he would have liked it. Mauro had acne so he started to get cured by a dermatologist, director in a big hospital, in august 1979. In January 1981 the dermatologist called me and proposed a new treatment, which was already tested in US and promised miracles.

TEXT
Doctor Gilliet prescribes Roaccutan to Mauro Weick. Two courses, between 81 and 83. The drug was still in the clinical test phase. After one year..

Heinz Weick
He called me in his office room and told me Dad, I can’t connect my brain anymore. I don’t understand when people are talking to me, I’m in a big confusion.

From the diary of Mauro Weick
I can’t concentrate myself, on anything. The meaning of words and sentences is kind of escaping from me, as it would be unstable or superficial. Even simple logical concepts make me desperate, because I can’t understand them.

Heinz Weick
In august 85 we luckily found a psychiatrist. After one month, he called me up and said Look, I can’t find any psychiatric disturbances in your son. Something is missing in the picture, he said. And organized a date with prof. Mumenthaler, in Bern. He was a famous neurologist, one of the best on a world scale at that time.

TEXT
Prof Mumenthaler couldn’t clear the case. The psychiatrist sent the boy to another neurologist, who suggested him to go in a clinic.

Heinz Weick
He came back home desperately crying, was difficult to cool him down. He said: I don’t want to land in the head-shrinker's hands. He was afraid to be locked for weeks and months in a psychiatric hospital.

TEXT
Mauro holds up: he inscribes himself at Pavia university, in Italy, to continue his studies. In July 1987..

Heinz Weick
According to the police, Mauro left Pavia early in the morning, but instead of coming home, where my wife was ironing, Mauro continued to the highway and reached the highest bridge. He wrote a letter with in big letters “Help”, sticked it on the car glass with the tape he bought before, and jumped down.

Heinz Weick
In 1998, I’ve been reading on two newspapers a very small article, big like two stamps, about the dangers of Roaccutan. But was small like that (makes the sign with the hands). I immediately wrote a letter to doctor Gilliet. He was very kind, gave me a date and in the meanwhile sent me a letter, letting me understand that there was absolutely no problem. Actually, when I went to visit him he said No, take it easy. He convinced me, and today I got it: he treated me like an idiot.

TEXT
In 2005, the Weick family see a TV reporting about Roaccutan. The man, former director of a private health insurance, today retired, decide to investigate. And found out many - and sad - surprises.

In 1998, the dermatologist dr Gilliet told him Take it easy. But in the meanwhile, he reported the case as "suspected suicide linked to Roaccutan" to the health authorities and to Roche. He wrote also a letter to a colleague based in Geneva:

“3 of my patients committed suicide".
“One of them is the son of a high ranked officer of an health insurance - I can expect legal consequences and that's why I try to clear the best I can this issue"

We asked for an interview to doctor Gilliet, but he preferred to answer to some written questions. Gilliet confirms: it was a clinical study, but he "can't recall the details". But he's happy to specify: in my medical dossier about this boy I can read the following line: 19 January 1983, sent papers to Basel".

Mike Papantonio, lawyer
..We’re not talking about a drug that cures heart disease or cures cancer. People would never make the choice to use this drug. Never. Once they understand how dangerous it is, there’s no logic, there’s no reasoning person that would say: I’m going to take Accutane to clear up pimples.

TEXT
Considering the risks, all over the world the regulatory authorities decided that Roaccutan could be prescribed only for severe cystic acne. Indeed, it is often ommonly given also for mild and middle acne.

Mother of Chelsea
There were some really really bad moments, a lot of pain was happening to her, she spent a lot of time in the bathroom and she would yell for me and I was going and sit with her, and I would see all the blood that would come out, and the tissue, and I would just hold her hand, and she just had some times she said I wished, Mom, I wasn’t alive.

Chelsea
I feel like I’ve been rubbed in certain areas, because I’m uncomfortable being in certain situations being around people, I am angry because I’m in pain and I don’t want this, it’s basically gonna be like that the rest of my life, and I do have to watch, you know, I need to take my medicine, do certain things I don’t want to do, like colonoscopy, I don’t want to do that, and when I do have my bad flare ups there are certain medicines I need to take, I don’t want to do that because they make me sick, do certain things that I don’t want but I have to.

Mother of Chelsea
I am angry. Because she was a fine, healthy, nothing wrong teenager, before she took Accutane.

TEXT
But the biggest number of reports is about psychiatric adverse events. In the Swiss database, they represent the 19 % - equal to 56 psychiatric events and 6 committed suicides. Often the onset of symptoms comes many months after the medication was stopped.

J. Douglas Bremner, psychiatrist
The effect is through protein transcription, that would imply that the effects would take longer to come on, but also would take longer to go away. Because, once you’ve started affecting protein transcription, you’re basically talking about changing the structure of the brain. It could take weeks to refer back to normal. It’s possible that some individuals would just stay that way. There will continue to be cases of suicide and depression. You know, Roche may continue to argue that they’re not related, that suicide is common or that there’s other extenuating circumstances. However, the science won’t stop. There’s even a new study that came out, it increases oxidative stress and causes DNA damage. So, I don’t think that… I think that most people would think twice about taking a drug that causes DNA damage. I mean, I certainly would.

TEXT
And the justice too, won't stop. Because the controversy is scientifical, but it's in court that the play is done. For health damages caused by Roaccutan, only in US there are currently 400 litigations - they'll be a 1000 before the end of 2007. In Florida is currently taking place the trial for the Bishop case. Charles Bishop, 15 years old, crashed with a small airplane in a skyscraper in Tampa. He was taking Roaccutan, too.

Heinz Weick
I want to make a call up. Is there anybody who took Roaccutan? Who suffered like my son Mauro have been suffering? There are maybe there parents who lost a son or a daughter thanks to this drug? I want to invite them all to stand up and come out - put beside the shame. Because we need badly to collect data, which can force the authorities to do finally something, take action to avoid similar traged

[bistro18]

Zu viel input, cache geschlossen.^^

[chribe]

Hab zwar nicht alles gelesen, aber man kann diese Diskussion unendlich weiter treiben, man kann sich drauf einigen das es bei manchen schlimme und andauernde NW gibt aber es noch viel mehr Menschen den es geholfen hat. Zumal man nie weiss bei solchen Berichten welche Vorerkrankung der Patient hatte und welche Dosis genommen wurde.

[THE FACE]

außerdem schau auf das datum - im welchen jahr es statt gefunden hat - heute wird regelmäßig blut abgenommen um zb die leberwerte u auch andere zu überprüfen
um sclimmere krankheiten u auch den tod zu vermeiden. es gibt bei dem ersten rezept ein zusatz heft im dem noch mal alles genau erläutet wird, wann u auch welche symptome man achten soll u den arzt aufsuchen soll. dann gibts bei den tabletten noch mal ein beipackzettel...
keiner behauptet das es ungefährilch ist... aber man warnt u macht heute mehr auf die nw aufmerksam um das schlimmste zu verhindern.

na ja, u etwa 98% von den (richtig/entsprechend) behandelten ist "gesund" geworden u geblieben.

[Josiane]

Don't worry. Es gibt etliche aktuelle Fälle, diese Nebenwirkungen begleiten das Medikament seit seiner Zulassung. Es gibt Sendungen mit demselben Thema aus dem letzten und aus diesem Jahr im Französischen Fernsehen, mit aktuellen Fällen von Personen, die während der Therapie mit Isotretinoin schwer erkrankt sind, nicht mehr lebensfähig sind und/oder sich das Leben genommen haben. Die Reportagen und einige Beispiele findest Du auf dieser Homepage: Association des Victimes du Roaccutane et G

Diese wurde von Eltern, die ihre Kinder verloren haben oder die schwer erkrankt sind, eingerichtet...und das bestimmt nicht aus "Jux und Dollerei". Behalte gerne weiter Deine ich-bezogene Haltung, es ist generell sehr interessant, wieviele in diesem Forum auf Beiträge wie die meinen reagieren und reagiert haben: keine Spur von Empathie für meine Schilderungen, dafür, dass unsere ganze Familie kaputt gegangen ist an der schweren Erkrankung meines Sohnes, weil dieses ganze Leid fast unmöglich zu ertragen ist. IM GEGENTEIL, Beleidigungen, Spott, Aggressivität. Niemand, der es nicht selbst erlebt hat, kann beurteilen, was es heißt, ein Kind durch Suizid zu verlieren, was es heißt, zusehen zu müssen, wie aus einem lebensfrohen glücklichen Menschen ein psychisches Wrack wird. Warum sollte ein Medikament einen Warnhinweis erhalten, wenn das alles lächerlich ist? Wir wurden zumindest nicht hingewiesen auf diese entsetzlichen Nebenwirkungen, und die erwähnten Blutuntersuchungen haben null Aussagekraft hinsichtlich bestimmter Erkrankungen und Veränderungen. Wenn ich die Beiträge hier lese, wird mir regelmäßig schlecht von der Verantwortungslosigkeit, mit der dieses Medikament verschrieben wird. Du würdest es sicher auch anders sehen, wenn Du einer der Personen wärst, die diese Nebenwirkung erfahren mußten.

[Josiane]

hier die erwähnte Homepage:Association des Victimes du Roaccutane et G
keine Ahnung, warum das beim Reinkopiern hier immer verloren geht

[Josiane]

Tageszeitung LONDON EVENING STANDARD vom 6.10.09:

Woman’s rail death ‘after acne drug gave her depression’, Anna Davis, Health Reporter, 06.10.09

The death of a woman who had been taking an anti-acne drug linked to suicide will be investigated at an inquest today.
Angela Lee, 28, stepped in front of a train at Seven Kings station, Ilford on 4 October last year.
She had been prescribed the drug Roaccutane for severe acne and experienced depression after taking it, lawyers representing her family said.
A jury at the inquest at Walthamstow coroner's court will hear evidence about her death. The medication is seen as one of the best treatments for severe acne and is said to be almost 90 per cent effective at clearing it.
However, 29 people in the UK taking Roaccutane are reported to have killed themselves since it was licensed in 1963. The Medicines and Healthcare Products Regulatory Agency has also recorded 22 suicide attempts and 39 patients considering suicide among those taking Roaccutane.

Roche, its manufacturer, has always rejected claims that it causes mental health problems, saying severe acne can lower self-esteem and cause depression.

Ms Lee, who was living in Ilford with her parents and brother at the time of her death, had suffered from ME, also known as chronic fatigue syndrome, since 1994.
She was prescribed Roaccutane in April last year and remained on the drug for three months.

Law firm Kingsley Napley, which is representing Ms Lee's family, said she suffered from many adverse effects, including increased depression during and after the acne treatment.

It said: “In May 2008, Angela's ME counsellor believed her to be at risk of suicide. She recommended that Angela be referred to the community mental health team for assessment. Unfortunately, no referral was made.”

Ross Brain, one of the solicitors representing the family, said: “While a link between Roaccutane and psychiatric changes has not been proven in medical studies, there is clear anecdotal evidence of some users of this drug experiencing acute depression, psychosis and/or suicidal tendencies.”

Roche said: “It would be inappropriate to comment until the findings of the inquest become public.”

Successful cure but doubts remain.
Roaccutane, which has the generic name Isotretinoin, can only be prescribed by a dermatologist. A four-month course clears most acne.
It works by decreasing the size of the sebaceous glands in the skin, which reduces the amount of sebum, a natural oil, that is produced. This stops glands blocking and also reduces skin inflammation.

Some people report huge improvements on online support groups. One wrote: “I've felt more confident in myself and haven't felt the need to wear heavy make-up.”

But others warn of its mental health effects. David Roberts, 20, from Liverpool, was found hanged in 2005 three months after he began taking Roaccutane. His father Fred told an inquest his son had been a “happy-go-lucky lad''.
Andrew Rebell, the coroner, recorded a narrative verdict, saying there was not enough evidence to link the death to Roaccutane.

[bistro18]

Welchen Zweck verfolgst du hier? Uns auf mögliche Schäden durch Iso hinzuweisen, indem du uns zahlreiche Artikel auf englisch auftischt?

[foxyfoxy]

Gemeint sind schwere Depressionen als Nebenwirkung von iso, die auch zum Selbstmord führen können!

[bistro18]

Ich hoffe doch mal, dass das die meisten wissen. Besser noch, das wünsch ich mir!

[Josiane]

BBC News vom 13. April 2006:

Teenager with acne killed himself
A teenager hanged himself just weeks after being given a controversial acne treatment drug, an inquest has heard.
Jason Spiller, 16, of Devon, had taken a course of Roaccutane. The families of two men who also killed themselves have blamed the drug for their deaths.
A Devon inquest on Thursday ruled Jason had killed himself, but found the drug was not "clearly" linked to depression.
Roaccutane's manufacturer Roche said there is no proven relationship between the drug and depression or suicide.
Jason's body was found by his mother Jean hanging from a raft in a barn on their farm in Honiton in April 2005.
He had been to see skin expert Dr Emily McGrath, a dermatologist at the Royal Devon and Exeter Hospital, 18 days earlier with severe acne.
Dr McGrath said in a statement to the inquest that Jason had suffered acne on his face, chest and back for the previous four years.
She said his GP felt he would be a candidate for Roaccutane. She warned Jason about possible side effects and said taking the drug could also lead to mood changes which should be monitored by his family.
Dr McGrath said: "Jason was not clinically depressed. He decided he would like to take the course."
It was unclear how many tablets Jason had taken in the time before his death but it may have been about 14. Toxicology tests were inconclusive.
Dr McGrath said the vitamin A derivative Roaccutane had been used since the early 1980s for treating acne and was "highly effective".

[bistro18]

Vor dem Verbot des Verkaufs von Ephedrin starben viele Leute daran, nun die Frage: Ist Ephedrin wirklich so ein Teufelszeug?

Hör langsam auf mit deinen Bemühungen. Die meisten haben es verstanden, worum es ging.

[foxyfoxy]

@bistro, Ja ephedrine ist Teufelszeug, geht sehr schnell an die Pumpe, damit kann man hammer Abnehmen oder locker bei der Tour de France mitfahren, sag bloss du kennst den film crank I nicht? wenn du den gesehen hast, dann wirst du wissen was ich meine:devil: